1. Extremely rare cases of mild contact dermatitis have been reported in people with pre-existing severe skin barrier damage, using products with concentrations >50%.
2. Industrial-grade 1,2-Propanediol is not approved for food or cosmetic use, as it may contain trace impurities; only USP/FCC/Ph. Eur. grade material is safe for consumer products.
3. It is not the same as ethylene glycol: 1,2-Propanediol has a drastically lower toxicity profile and is not classified as a toxic substance for consumer use.

1,2-Propanediol is a well-studied, fully regulated, and safe ingredient for standard use in food, clean beauty, pharmaceuticals, and household products. Its widespread approval from global regulators, paired with decades of toxicological data, confirms it is a reliable, low-risk option for non-toxic formulation and sustainable product development in 2026.